RRC ID 80791
Author Banerjee N, Rojas Palato EJ, Shih PY, Sternberg PW, Hallem EA.
Title Distinct neurogenetic mechanisms establish the same chemosensory valence state at different life stages in Caenorhabditis elegans.
Journal G3 (Bethesda)
Abstract An animal's preference for many chemosensory cues remains constant despite dramatic changes in the animal's internal state. The mechanisms that maintain chemosensory preference across different physiological contexts remain poorly understood. We previously showed that distinct patterns of neural activity and motor output are evoked by carbon dioxide (CO2) in starved adults vs dauers of Caenorhabditis elegans, despite the two life stages displaying the same preference (attraction) for CO2. However, how the distinct CO2-evoked neural dynamics and motor patterns contribute to CO2 attraction at the two life stages remained unclear. Here, using a CO2 chemotaxis assay, we show that different interneurons are employed to drive CO2 attraction at the two life stages. We also investigate the molecular mechanisms that mediate CO2 attraction in dauers vs adults. We show that insulin signaling promotes CO2 attraction in dauers but not starved adults and that different combinations of neurotransmitters and neuropeptides are used for CO2 attraction at the two life stages. Our findings provide new insight into the distinct molecular and cellular mechanisms used by C. elegans at two different life stages to generate attractive behavioral responses to CO2.
Volume 14(2)
Published 2024-2-7
DOI 10.1093/g3journal/jkad271
PII 7444311
PMID 38092065
PMC PMC10849362
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins* / genetics Carbon Dioxide Interneurons / physiology Neuropeptides*
C.elegans tm2416 tm790