論文 - 詳細
| RRC ID | 80819 |
|---|---|
| 著者 | Li R, Xu Y, Wen X, Chen YH, Wang PZ, Zhao JL, Wu PP, Wu JJ, Liu H, Huang JH, Li SJ, Wu ZX. |
| タイトル | GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold. |
| ジャーナル | Cell Rep |
| Abstract |
Organisms sensing environmental cues and internal states and integrating the sensory information to control fecundity are essential for survival and proliferation. The present study finds that a moderate cold temperature of 11°C reduces egg laying in Caenorhabditis elegans. ASEL and AWC neurons sense the cold via GCY-20 signaling and act antagonistically on egg laying through the ASEL and AWC/AIA/HSN circuits. Upon cold stimulation, ASEL and AWC release glutamate to activate and inhibit AIA interneurons by acting on highly and lowly sensitive ionotropic GLR-2 and GLC-3 receptors, respectively. AIA inhibits HSN motor neuron activity via acetylcholinergic ACR-14 receptor signaling and suppresses egg laying. Thus, ASEL and AWC initiate and reduce the cold suppression of egg laying. ASEL's action on AIA and egg laying dominates AWC's action. The biased opposite actions of these neurons on egg laying provide animals with a precise adaptation of reproductive behavior to environmental temperatures. |
| 巻・号 | 43(2) |
| ページ | 113708 |
| 公開日 | 2024-2-27 |
| DOI | 10.1016/j.celrep.2024.113708 |
| PII | S2211-1247(24)00036-6 |
| PMID | 38294902 |
| MeSH | Animals Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Cold Temperature Motor Neurons / physiology Signal Transduction / physiology |
| リソース情報 | |
| 線虫 | tm373 tm5819 |