Reference - Detail
| RRC ID | 80836 |
|---|---|
| Author | Abay-Nørgaard S, Tapia MC, Zeijdner M, Kim JH, Won KJ, Porse B, Salcini AE. |
| Title | Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis. |
| Journal | Life Sci Alliance |
| Abstract |
Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- or transgenerational epigenetic inheritance. It remains unknown if genetically and conditionally induced aberrant epigenetic states can influence the development of the nervous system across generations. Here, we show, using Caenorhabditis elegans as a model system, that alteration of H3K4me3 levels in the parental generation, caused by genetic manipulation or changes in parental conditions, has, respectively, trans- and intergenerational effects on H3K4 methylome, transcriptome, and nervous system development. Thus, our study reveals the relevance of H3K4me3 transmission and maintenance in preventing long-lasting deleterious effects in nervous system homeostasis. |
| Volume | 6(8) |
| Published | 2023-8-1 |
| DOI | 10.26508/lsa.202301970 |
| PII | 6/8/e202301970 |
| PMID | 37225426 |
| PMC | PMC10209521 |
| MeSH | Animals Caenorhabditis elegans* / genetics Epigenome* Epigenomics Homeostasis / genetics Methylation |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 14 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| C.elegans | tm1905 tm1200 |