論文 - 詳細
| RRC ID | 80842 |
|---|---|
| 著者 | Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A. |
| タイトル | Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids. |
| ジャーナル | Nat Cell Biol |
| Abstract |
Dietary mono-unsaturated fatty acids (MUFAs) are linked to longevity in several species. But the mechanisms by which MUFAs extend lifespan remain unclear. Here we show that an organelle network involving lipid droplets and peroxisomes is critical for MUFA-induced longevity in Caenorhabditis elegans. MUFAs upregulate the number of lipid droplets in fat storage tissues. Increased lipid droplet number is necessary for MUFA-induced longevity and predicts remaining lifespan. Lipidomics datasets reveal that MUFAs also modify the ratio of membrane lipids and ether lipids-a signature associated with decreased lipid oxidation. In agreement with this, MUFAs decrease lipid oxidation in middle-aged individuals. Intriguingly, MUFAs upregulate not only lipid droplet number but also peroxisome number. A targeted screen identifies genes involved in the co-regulation of lipid droplets and peroxisomes, and reveals that induction of both organelles is optimal for longevity. Our study uncovers an organelle network involved in lipid homeostasis and lifespan regulation, opening new avenues for interventions to delay aging. |
| 巻・号 | 25(5) |
| ページ | 672-684 |
| 公開日 | 2023-5-1 |
| DOI | 10.1038/s41556-023-01136-6 |
| PII | 10.1038/s41556-023-01136-6 |
| PMID | 37127715 |
| PMC | PMC10185472 |
| MeSH | Animals Caenorhabditis elegans / genetics Fatty Acids Fatty Acids, Unsaturated Humans Lipid Droplets Longevity* / genetics Middle Aged Peroxisomes* |
| リソース情報 | |
| 線虫 | tm2100 |