論文 - 詳細
| RRC ID | 80845 |
|---|---|
| 著者 | Zhan X, Chen C, Niu L, Du X, Lei Y, Dan R, Wang ZW, Liu P. |
| タイトル | Locomotion modulates olfactory learning through proprioception in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Locomotor activities can enhance learning, but the underlying circuit and synaptic mechanisms are largely unknown. Here we show that locomotion facilitates aversive olfactory learning in C. elegans by activating mechanoreceptors in motor neurons, and transmitting the proprioceptive information thus generated to locomotion interneurons through antidromic-rectifying gap junctions. The proprioceptive information serves to regulate experience-dependent activities and functional coupling of interneurons that process olfactory sensory information to produce the learning behavior. Genetic destruction of either the mechanoreceptors in motor neurons, the rectifying gap junctions between the motor neurons and locomotion interneurons, or specific inhibitory synapses among the interneurons impairs the aversive olfactory learning. We have thus uncovered an unexpected role of proprioception in a specific learning behavior as well as the circuit, synaptic, and gene bases for this function. |
| 巻・号 | 14(1) |
| ページ | 4534 |
| 公開日 | 2023-7-27 |
| DOI | 10.1038/s41467-023-40286-x |
| PII | 10.1038/s41467-023-40286-x |
| PMID | 37500635 |
| PMC | PMC10374624 |
| MeSH | Animals Avoidance Learning Caenorhabditis elegans* / genetics Gap Junctions* / physiology Interneurons / physiology Locomotion / physiology Proprioception / physiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm1896 tm1552 tm2071 tm3524 tm2738 tm3268 tm6556 |