Reference - Detail
| RRC ID | 80846 |
|---|---|
| Author | Teuscher AC, Statzer C, Goyala A, Domenig SA, Schoen I, Hess M, Hofer AM, Fossati A, Vogel V, Goksel O, Aebersold R, Ewald CY. |
| Title | Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans. |
| Journal | Nat Commun |
| Abstract |
Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM composition changes in healthy aging remains unclear. Here we perform proteomics and in-vivo monitoring to systematically investigate ECM composition (matreotype) during aging in C. elegans revealing three distinct collagen dynamics. Longevity interventions slow age-related collagen stiffening and prolong the expression of collagens that are turned over. These prolonged collagen dynamics are mediated by a mechanical feedback loop of hemidesmosome-containing structures that span from the exoskeletal ECM through the hypodermis, basement membrane ECM, to the muscles, coupling mechanical forces to adjust ECM gene expression and longevity via the transcriptional co-activator YAP-1 across tissues. Our results provide in-vivo evidence that coordinated ECM remodeling through mechanotransduction is required and sufficient to promote longevity, offering potential avenues for interventions targeting ECM dynamics. |
| Volume | 15(1) |
| Pages | 276 |
| Published | 2024-1-4 |
| DOI | 10.1038/s41467-023-44409-2 |
| PII | 10.1038/s41467-023-44409-2 |
| PMID | 38177158 |
| PMC | PMC10766642 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Collagen / metabolism Extracellular Matrix / metabolism Homeostasis Longevity* / physiology Mechanotransduction, Cellular Transcription Factors / genetics Transcription Factors / metabolism YAP-Signaling Proteins |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 62 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm8818 tm1416 tm6673 tm548 tm385 tm1092 |