| RRC ID |
80849
|
| 著者 |
Stojanovski K, Gheorghe I, Lenart P, Lanjuin A, Mair WB, Towbin BD.
|
| タイトル |
Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Even slight imbalance between the growth rate of different organs can accumulate to a large deviation from their appropriate size during development. Here, we use live imaging of the pharynx of C. elegans to ask if and how organ size scaling nevertheless remains uniform among individuals. Growth trajectories of hundreds of individuals reveal that pharynxes grow by a near constant volume per larval stage that is independent of their initial size, such that undersized pharynxes catch-up in size during development. Tissue-specific depletion of RAGA-1, an activator of mTOR and growth, shows that maintaining correct pharynx-to-body size proportions involves a bi-directional coupling between pharynx size and body growth. In simulations, this coupling cannot be explained by limitation of food uptake alone, and genetic experiments reveal an involvement of the mechanotransducing transcriptional co-regulator yap-1. Our data suggests that mechanotransduction coordinates pharynx growth with other tissues, ensuring body plan uniformity among individuals.
|
| 巻・号 |
14(1)
|
| ページ |
7564
|
| 公開日 |
2023-11-20
|
| DOI |
10.1038/s41467-023-43230-1
|
| PII |
10.1038/s41467-023-43230-1
|
| PMID |
37985670
|
| PMC |
PMC10661912
|
| MeSH |
Animals
Caenorhabditis elegans* / genetics
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Humans
Mechanotransduction, Cellular
Pharynx / metabolism
YAP-Signaling Proteins
|
| リソース情報 |
| 線虫 |
tm1416 |
