Reference - Detail
| RRC ID | 80851 |
|---|---|
| Author | Vérièpe-Salerno J, Podavini S, Long MJC, Kolotuev I, Cuendet M, Thome M. |
| Title | MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans. |
| Journal | Autophagy Rep |
| Abstract |
The caspase-like protease MALT1 promotes immune responses and oncogenesis in mammals by activating the transcription factor NF-κB. MALT1 is remarkably conserved from mammals to simple metazoans devoid of NF-κB homologs, like the nematode C. elegans. To discover more ancient, NF-κB -independent MALT1 functions, we analysed the phenotype of C. elegans upon silencing of MALT-1 expression systemically or in a tissue-specific manner. MALT-1 silencing in the intestine caused a significant increase in life span, whereas intestinal overexpression of MALT-1 shortened life expectancy. Interestingly, MALT-1-deficient animals showed higher constitutive levels of autophagy in the intestine, which were particularly evident in aged or starved nematodes. Silencing of the autophagy regulators ATG-13, BEC-1 or LGG-2, but not the TOR homolog LET-363, reversed lifespan extension caused by MALT-1 deficiency. These findings suggest that MALT-1 limits the lifespan of C. elegans by acting as an inhibitor of an early step of autophagy in the intestine. |
| Volume | 2(1) |
| Pages | 2277584 |
| Published | 2023-11-9 |
| DOI | 10.1080/27694127.2023.2277584 |
| PMID | 38510643 |
| PMC | PMC7615756 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm289 |