| RRC ID |
80854
|
| 著者 |
Zhang R, Fang J, Qi T, Zhu S, Yao L, Fang G, Li Y, Zang X, Xu W, Hao W, Liu S, Yang D, Chen D, Yang J, Ma X, Wu L.
|
| タイトル |
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria.
|
| ジャーナル |
Cell Res
|
| Abstract |
Maternal age at childbearing has continued to increase in recent decades. However, whether and how it influences offspring adult traits are largely unknown. Here, using adult body size as the primary readout, we reveal that maternal rather than paternal age has an evolutionarily conserved effect on offspring adult traits in humans, Drosophila, and Caenorhabditis elegans. Elucidating the mechanisms of such effects in humans and other long-lived animals remains challenging due to their long life course and difficulties in conducting in vivo studies. We thus employ the short-lived and genetically tractable nematode C. elegans to explore the mechanisms underlying the regulation of offspring adult trait by maternal aging. By microscopic analysis, we find that old worms transmit aged mitochondria with a donut-like shape to offspring. These mitochondria are rejuvenated in the offspring's early life, with their morphology fully restored before adulthood in an AMPK-dependent manner. Mechanistically, we demonstrate that early-life mitochondrial dysfunction activates AMPK, which in turn not only alleviates mitochondrial abnormalities but also activates TGFβ signaling to increase offspring adult size. Together, our findings provide mechanistic insight into the ancient role of maternal aging in shaping the traits of adult offspring.
|
| 巻・号 |
33(11)
|
| ページ |
821-834
|
| 公開日 |
2023-11-1
|
| DOI |
10.1038/s41422-023-00854-8
|
| PII |
10.1038/s41422-023-00854-8
|
| PMID |
37500768
|
| PMC |
PMC10624822
|
| MeSH |
AMP-Activated Protein Kinases*
Adult
Aged
Aging / physiology
Animals
Body Size
Caenorhabditis elegans*
Humans
Mitochondria
|
| リソース情報 |
| 線虫 |
tm4776
tm1108
tm1133
tm1125 |
