| RRC ID |
80873
|
| Author |
Ray S, Gurung P, Manning RS, Kravchuk AA, Singhvi A.
|
| Title |
Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing.
|
| Journal |
Cell Rep
|
| Abstract |
Glia interact with multiple neurons, but it is unclear whether their interactions with each neuron are different. Our interrogation at single-cell resolution reveals that a single glial cell exhibits specificity in its interactions with different contacting neurons. Briefly, C. elegans amphid sheath (AMsh) glia apical-like domains contact 12 neuron-endings. At these ad-neuronal membranes, AMsh glia localize the K/Cl transporter KCC-3 to a microdomain exclusively around the thermosensory AFD neuron to regulate its properties. Glial KCC-3 is transported to ad-neuronal regions, where distal cilia of non-AFD glia-associated chemosensory neurons constrain it to a microdomain at AFD-contacting glial membranes. Aberrant KCC-3 localization impacts both thermosensory (AFD) and chemosensory (non-AFD) neuron properties. Thus, neurons can interact non-synaptically through a shared glial cell by regulating microdomain localization of its cues. As AMsh and glia across species compartmentalize multiple cues like KCC-3, we posit that this may be a broadly conserved glial mechanism that modulates information processing across multimodal circuits.
|
| Volume |
43(3)
|
| Pages |
113844
|
| Published |
2024-3-26
|
| DOI |
10.1016/j.celrep.2024.113844
|
| PII |
S2211-1247(24)00172-4
|
| PMID |
38421867
|
| MeSH |
Animals
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / metabolism
Cilia / metabolism
Neuroglia / metabolism
Neurons / metabolism
|
| Resource |
| C.elegans |
tm487 |
