論文 - 詳細
| RRC ID | 80879 |
|---|---|
| 著者 | Papandreou ME, Konstantinidis G, Tavernarakis N. |
| タイトル | Nucleophagy delays aging and preserves germline immortality. |
| ジャーナル | Nat Aging |
| Abstract |
Marked alterations in nuclear ultrastructure are a universal hallmark of aging, progeroid syndromes and other age-related pathologies. Here we show that autophagy of nuclear proteins is an important determinant of fertility and aging. Impairment of nucleophagy diminishes stress resistance, germline immortality and longevity. We found that the nematode Caenorhabditis elegans nuclear envelope anchor protein, nuclear anchorage protein 1 (ANC-1) and its mammalian ortholog nesprin-2 are cleared out by autophagy and restrict nucleolar size, a biomarker of aging. We further uncovered a germline immortality assurance mechanism, which involves nucleolar degradation at the most proximal oocyte by ANC-1 and key autophagic components. Perturbation of this clearance pathway causes tumor-like structures in C. elegans, and genetic ablation of nesprin-2 causes ovarian carcinomas in mice. Thus, autophagic recycling of nuclear components is a conserved soma longevity and germline immortality mechanism that promotes youthfulness and delays aging under conditions of stress. |
| 巻・号 | 3(1) |
| ページ | 34-46 |
| 公開日 | 2023-1-1 |
| DOI | 10.1038/s43587-022-00327-4 |
| PII | 10.1038/s43587-022-00327-4 |
| PMID | 37118512 |
| PMC | PMC10154226 |
| MeSH | Aging* / genetics Animals Autophagy / genetics Caenorhabditis elegans* / genetics Germ Cells Mammals Mice |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 111 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5755 |