論文 - 詳細
| RRC ID | 80888 |
|---|---|
| 著者 | Szczepańska A, Olek K, Kołodziejska K, Yu J, Ibrahim AT, Adamkiewicz L, Schroeder FC, Pokrzywa W, Turek M. |
| タイトル | Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Extracellular vesicles (EVs) are integral to numerous biological processes, yet it is unclear how environmental factors or interactions among individuals within a population affect EV-regulated systems. In Caenorhabditis elegans, the evolutionarily conserved large EVs, known as exophers, are part of a maternal somatic tissue resource management system. Consequently, the offspring of individuals exhibiting active exopher biogenesis (exophergenesis) develop faster. Our research focuses on unraveling the complex inter-tissue and social dynamics that govern exophergenesis. We found that ascr#10, the primary male pheromone, enhances exopher production in hermaphrodites, mediated by the G-protein-coupled receptor STR-173 in ASK sensory neurons. In contrast, pheromone produced by other hermaphrodites, ascr#3, diminishes exophergenesis within the population. This process is regulated via the neuropeptides FLP-8 and FLP-21, which originate from the URX and AQR/PQR/URX neurons, respectively. Our results reveal a regulatory network that controls the production of somatic EV by the nervous system in response to social signals. |
| 巻・号 | 15(1) |
| ページ | 2715 |
| 公開日 | 2024-3-28 |
| DOI | 10.1038/s41467-024-47016-x |
| PII | 10.1038/s41467-024-47016-x |
| PMID | 38548742 |
| PMC | PMC10978837 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins* / genetics Extracellular Vesicles* Humans Male Neurons / physiology Pheromones |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm604 tm741 |