論文 - 詳細
| RRC ID | 80897 |
|---|---|
| 著者 | Park K, Jayadev R, Payne SG, Kenny-Ganzert IW, Chi Q, Costa DS, Ramos-Lewis W, Thendral SB, Sherwood DR. |
| タイトル | Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues. |
| ジャーナル | Elife |
| Abstract |
Separate tissues connect through adjoining basement membranes to carry out molecular barrier, exchange, and organ support functions. Cell adhesion at these connections must be robust and balanced to withstand independent tissue movement. Yet, how cells achieve synchronized adhesion to connect tissues is unknown. Here, we have investigated this question using the Caenorhabditis elegans utse-seam tissue connection that supports the uterus during egg-laying. Through genetics, quantitative fluorescence, and cell-specific molecular disruption, we show that type IV collagen, which fastens the linkage, also activates the collagen receptor discoidin domain receptor-2 (DDR-2) in both the utse and seam. RNAi depletion, genome editing, and photobleaching experiments revealed that DDR-2 signals through LET-60/Ras to coordinately strengthen an integrin adhesion in the utse and seam that stabilizes their connection. These results uncover a synchronizing mechanism for robust adhesion during tissue connection, where collagen both affixes the linkage and signals to both tissues to bolster their adhesion. |
| 巻・号 | 12 |
| 公開日 | 2023-7-5 |
| DOI | 10.7554/eLife.87037 |
| PII | 87037 |
| PMID | 37405383 |
| PMC | PMC10328527 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Cell Adhesion / physiology Collagen / metabolism Discoidin Domain Receptor 2* / metabolism Discoidin Domain Receptors / metabolism Female Integrins* Signal Transduction |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm382 tm797 |