| RRC ID |
80918
|
| 著者 |
Mishra S, Dabaja M, Akhlaq A, Pereira B, Marbach K, Rovcanin M, Chandra R, Caballero A, Fernandes de Abreu D, Ch'ng Q, Alcedo J.
|
| タイトル |
Specific sensory neurons and insulin-like peptides modulate food type-dependent oogenesis and fertilization in Caenorhabditis elegans.
|
| ジャーナル |
Elife
|
| Abstract |
An animal's responses to environmental cues are critical for its reproductive program. Thus, a mechanism that allows the animal to sense and adjust to its environment should make for a more efficient reproductive physiology. Here, we demonstrate that in Caenorhabditis elegans specific sensory neurons influence onset of oogenesis through insulin signaling in response to food-derived cues. The chemosensory neurons ASJ modulate oogenesis onset through the insulin-like peptide (ILP) INS-6. In contrast, other sensory neurons, the olfactory neurons AWA, regulate food type-dependent differences in C. elegans fertilization rates, but not onset of oogenesis. AWA modulates fertilization rates at least partly in parallel to insulin receptor signaling, since the insulin receptor DAF-2 regulates fertilization independently of food type, which requires ILPs other than INS-6. Together our findings suggest that optimal reproduction requires the integration of diverse food-derived inputs through multiple neuronal signals acting on the C. elegans germline.
|
| 巻・号 |
12
|
| 公開日 |
2023-11-17
|
| DOI |
10.7554/eLife.83224
|
| PII |
83224
|
| PMID |
37975568
|
| PMC |
PMC10665013
|
| MeSH |
Animals
Caenorhabditis elegans*
Caenorhabditis elegans Proteins* / genetics
Fertilization
Insulin
Receptor, Insulin
Sensory Receptor Cells / physiology
|
| リソース情報 |
| 線虫 |
tm2308
tm2416 |
