論文 - 詳細
| RRC ID | 80927 |
|---|---|
| 著者 | Ezhil Buvani AP, Subramaniam K. |
| タイトル | The C. elegans gene gvd-1 promotes late larval development and germ cell proliferation. |
| ジャーナル | Biol Open |
| Abstract |
Limiting maternal resources necessitates deferring the development of adult-specific structures, notably the reproductive structures, to the postembryonic phase. These structures form postembryonically from blast cells generated during embryogenesis. A close coordination of developmental timing and pattern among the various postembryonic cell lineages is essential to form a functional adult. Here, we show that the C. elegans gene gvd-1 is essential for the development of several structures that form during the late larval stages. In gvd-1 mutant animals, blast cells that normally divide during the late larval stages (L3 and L4) fail to divide. In addition, germ cell proliferation is also severely reduced in these animals. Expression patterns of relevant reporter transgenes revealed a delay in G1/S transition in the vulval precursor cell P6.p and cytokinesis failure in seam cells in gvd-1 larvae. Our analyses of GVD-1::GFP transgenes indicate that GVD-1 is expressed in both soma and germ line, and functions in both. Sequence comparisons revealed that the sequence of gvd-1 is conserved only among nematodes, which does not support a broadly conserved housekeeping function for gvd-1. Instead, our results indicate a crucial role for gvd-1 that is specific to the larval development of nematodes. |
| 巻・号 | 12(7) |
| 公開日 | 2023-7-15 |
| DOI | 10.1242/bio.059978 |
| PII | 316697 |
| PMID | 37310364 |
| PMC | PMC10320718 |
| MeSH | Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Cell Lineage Cell Proliferation Germ Cells / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Blogs |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm2403 |