論文 - 詳細
| RRC ID | 80944 |
|---|---|
| 著者 | Franziscus CA, Ritz D, Kappel NC, Solinger JA, Schmidt A, Spang A. |
| タイトル | The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures. |
| ジャーナル | FEBS Open Bio |
| Abstract |
Post-translational modifications are key in the regulation of activity, structure, localization, and stability of most proteins in eukaryotes. Phosphorylation is potentially the most studied post-translational modification, also due to its reversibility and thereby the regulatory role this modification often plays. While most research attention was focused on kinases in the past, phosphatases remain understudied, most probably because the addition and presence of the modification is more easily studied than its removal and absence. Here, we report the identification of an uncharacterized protein tyrosine phosphatase PPH-7 in C. elegans, a member of the evolutionary conserved PTPN family of phosphatases. Lack of PPH-7 function led to reduction of fertility and embryonic lethality at elevated temperatures. Proteomics revealed changes in the regulation of targets of the von Hippel-Lindau (VHL) E3 ligase, suggesting a potential role for PPH-7 in the regulation of VHL. |
| 巻・号 | 14(3) |
| ページ | 390-409 |
| 公開日 | 2024-3-1 |
| DOI | 10.1002/2211-5463.13771 |
| PMID | 38320757 |
| PMC | PMC10909979 |
| MeSH | Animals Caenorhabditis elegans* / metabolism Embryonic Development / genetics Fertility / genetics Protein Tyrosine Phosphatases Temperature Von Hippel-Lindau Tumor Suppressor Protein* / metabolism |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5332 tm5532 tm533 |