Reference - Detail
| RRC ID | 80947 |
|---|---|
| Author | Lemieux GA, Yoo S, Lin L, Vohra M, Ashrafi K. |
| Title | The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels. |
| Journal | Genes Dev |
| Abstract |
Reductions in brain kynurenic acid levels, a neuroinhibitory metabolite, improve cognitive function in diverse organisms. Thus, modulation of kynurenic acid levels is thought to have therapeutic potential in a range of brain disorders. Here we report that the steroid 5-androstene 3β, 17β-diol (ADIOL) reduces kynurenic acid levels and promotes associative learning in Caenorhabditis elegans We identify the molecular mechanisms through which ADIOL links peripheral metabolic pathways to neural mechanisms of learning capacity. Moreover, we show that in aged animals, which normally experience rapid cognitive decline, ADIOL improves learning capacity. The molecular mechanisms that underlie the biosynthesis of ADIOL as well as those through which it promotes kynurenic acid reduction are conserved in mammals. Thus, rather than a minor intermediate in the production of sex steroids, ADIOL is an endogenous hormone that potently regulates learning capacity by causing reductions in neural kynurenic acid levels. |
| Volume | 37(21-24) |
| Pages | 998-1016 |
| Published | 2023-12-26 |
| DOI | 10.1101/gad.350745.123 |
| PII | gad.350745.123 |
| PMID | 38092521 |
| PMC | PMC10760639 |
| MeSH | Animals Hormones Kynurenic Acid* / pharmacology Mammals Steroids* |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1376 tm2654 tm4529 tm7443 tm886 tm4713 |