Reference - Detail
| RRC ID | 80957 |
|---|---|
| Author | Michaeli L, Spector E, Haeussler S, Carvalho CA, Grobe H, Abu-Shach UB, Zinger H, Conradt B, Broday L. |
| Title | ULP-2 SUMO protease regulates UPRmt and mitochondrial homeostasis in Caenorhabditis elegans. |
| Journal | Free Radic Biol Med |
| Abstract |
Mitochondria are the powerhouses of cells, responsible for energy production and regulation of cellular homeostasis. When mitochondrial function is impaired, a stress response termed mitochondrial unfolded protein response (UPRmt) is initiated to restore mitochondrial function. Since mitochondria and UPRmt are implicated in many diseases, it is important to understand UPRmt regulation. In this study, we show that the SUMO protease ULP-2 has a key role in regulating mitochondrial function and UPRmt. Specifically, down-regulation of ulp-2 suppresses UPRmt and reduces mitochondrial membrane potential without significantly affecting cellular ROS. Mitochondrial networks are expanded in ulp-2 null mutants with larger mitochondrial area and increased branching. Moreover, the amount of mitochondrial DNA is increased in ulp-2 mutants. Downregulation of ULP-2 also leads to alterations in expression levels of mitochondrial genes involved in protein import and mtDNA replication, however, mitophagy remains unaltered. In summary, this study demonstrates that ULP-2 is required for mitochondrial homeostasis and the UPRmt. |
| Volume | 214 |
| Pages | 19-27 |
| Published | 2024-3-1 |
| DOI | 10.1016/j.freeradbiomed.2024.01.050 |
| PII | S0891-5849(24)00058-3 |
| PMID | 38301974 |
| PMC | PMC10929073 |
| MeSH | Animals Caenorhabditis elegans* / genetics DNA, Mitochondrial / genetics Homeostasis Mitochondria / genetics Peptide Hydrolases* |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1133 tm1108 |