| RRC ID |
80981
|
| 著者 |
He X, Kusuya Y, Hagiwara D, Toyotome T, Arai T, Bian C, Nagayama M, Shibata S, Watanabe A, Takahashi H.
|
| タイトル |
Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance.
|
| ジャーナル |
Commun Biol
|
| Abstract |
Aspergillus fumigatus is a pathogenic fungus with a global distribution. The emergence of azole-resistant A. fumigatus (ARAf) other than the TR-mutants is a problem in Japan. Additionally, the genetic diversity of A. fumigatus strains in Japan remains relatively unknown. Here we show the diversity in the A. fumigatus strains isolated in Japan as well as the complexity in the global distribution of the pathogenic strains. First, we analyzed the genome sequences of 171 strains from Japan as well as the antifungal susceptibility of these strains. Next, we conducted a population analysis of 876 strains by combining the available genomic data for strains isolated worldwide, which were grouped in six clusters. Finally, a genome-wide association study identified the genomic loci associated with ARAf strains, but not the TR-mutants. These results highlight the complexity of the genomic mechanism underlying the emergence of ARAf strains other than the TR-mutants.
|
| 巻・号 |
7(1)
|
| ページ |
274
|
| 公開日 |
2024-3-14
|
| DOI |
10.1038/s42003-024-05902-6
|
| PII |
10.1038/s42003-024-05902-6
|
| PMID |
38486002
|
| PMC |
PMC10940670
|
| MeSH |
Aspergillus fumigatus* / genetics
Azoles* / pharmacology
Drug Resistance, Fungal / genetics
Genome-Wide Association Study
Genomics
Japan
|
| IF |
4.165
|
| リソース情報 |
| 病原真核微生物 |
Aspergillus fumigatus IFM 57543-2a, IFM 59984-1a, IFM 60237b, IFM 65468b, IFM 61578-1, IFM 62103c, IFM 62105-1c, IFM 62628, IFM 63240d, IFM 63537-2d , IFM 63714-1d, IFM 64173d, IFM 63768e, IFM 63772e, IFM 64258f, IFM 63805f, IFM 64259, IFM 63345, IFM 63559-1g, IFM 63560-1g, IFM 64160-1 (OKH34), IFM 65494 |
