論文 - 詳細
| RRC ID | 80982 |
|---|---|
| 著者 | Azami H, Watanabe Y, Sakai K, Nakahara H, Kojima H, Tokiwa T, Nonaka K, Noguchi Y, Nagano Y, Hirose T, Sunazuka T, Matsui H, Arima N, Abe K, Hanaki H, Iwatsuki M. |
| タイトル | Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound, tyroscherin (2). The structure of 1 was elucidated as a new analog of 2 by MS and NMR analyses. The absolute configuration of 1 was determined by chemical derivatization. Both compounds showed potent in vitro antifungal activity against clinically isolated Candida auris strains, with MIC values ranging from 0.0625 to 4 µg ml-1. |
| 巻・号 | 77(3) |
| ページ | 156-162 |
| 公開日 | 2024-3-1 |
| DOI | 10.1038/s41429-023-00696-x |
| PII | 10.1038/s41429-023-00696-x |
| PMID | 38200163 |
| MeSH | Antifungal Agents* / pharmacology Antifungal Agents* / therapeutic use Candida auris Epinephrine / analogs & derivatives* Fatty Alcohols* Fungi Microbial Sensitivity Tests Scedosporium* |
| IF | 2.668 |
| リソース情報 | |
| 病原真核微生物 | Candida auris IFM 65764, IFM 65832 |