論文 - 詳細
| RRC ID | 81129 |
|---|---|
| 著者 | Keary KM 3rd, Gu QH, Chen J, Li Z. |
| タイトル | Dendritic distribution of autophagosomes underlies pathway-selective induction of LTD. |
| ジャーナル | Cell Rep |
| Abstract |
The mechanism of long-term depression (LTD), a cellular substrate for learning, memory, and behavioral flexibility, is extensively studied in Schaffer collateral (SC) synapses, with inhibition of autophagy identified as a key factor. SC inputs terminate at basal and proximal apical dendrites, whereas distal apical dendrites receive inputs from the temporoammonic pathway (TAP). Here, we demonstrate that TAP and SC synapses have a shared LTD mechanism reliant on NMDA receptors, caspase-3, and autophagy inhibition. Despite this shared LTD mechanism, proximal apical dendrites contain more autophagosomes than distal apical dendrites. Additionally, unlike SC LTD, which diminishes with age, TAP LTD persists into adulthood. Our previous study shows that the high autophagy in adulthood disallows SC LTD induction. The reduction of autophagosomes from proximal to distal dendrites, combined with distinct LTD inducibility at SC and TAP synapses, suggests a model where the differential distribution of autophagosomes in dendrites gates LTD inducibility at specific circuits. |
| 巻・号 | 42(8) |
| ページ | 112898 |
| 公開日 | 2023-8-29 |
| DOI | 10.1016/j.celrep.2023.112898 |
| PII | S2211-1247(23)00909-9 |
| PMID | 37516958 |
| PMC | PMC10528062 |
| MeSH | Animals Autophagosomes* / physiology Autophagy CA1 Region, Hippocampal / cytology CA1 Region, Hippocampal / physiology Caspase 3 / metabolism Dendrites* / physiology Hippocampus* / cytology Hippocampus* / physiology Long-Term Synaptic Depression* Mice Mice, Inbred C57BL Nerve Tissue Proteins / metabolism Receptors, N-Methyl-D-Aspartate / metabolism Synapses* / physiology |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02975 |