Reference - Detail
| RRC ID | 81282 |
|---|---|
| Author | Wang J, Hashimoto Y, Hiemori-Kondo M, Nakamoto A, Sakai T, Ye W, Abe-Kanoh N. |
| Title | Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
The process of apoptotic cell clearance by phagocytes, known as efferocytosis, plays an essential role in maintaining homeostasis. Defects in efferocytosis can lead to inflammatory diseases such as atherosclerosis and autoimmune disorders. Therefore, the maintenance and promotion of efferocytosis are considered crucial for preventing these diseases. In this study, we observed that resveratrol, a representative functional food ingredient, and its glycoside, piceid, promoted efferocytosis in both human THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate and peritoneal macrophages from thioglycolate-elicited mice. Resveratrol and piceid significantly increased mRNA expression and protein secretion of MFG-E8 in THP-1 macrophages. Furthermore, the activation of efferocytosis and the increment in MFG-E8 protein secretion caused by resveratrol or piceid treatment were canceled by MFG-E8 knockdown in THP-1 macrophages. In conclusion, we have demonstrated for the first time that resveratrol and piceid promote efferocytosis through the upregulation of MFG-E8 excretion in human THP-1 macrophages. |
| Published | 2024-6-3 |
| DOI | 10.1093/bbb/zbae079 |
| PII | 7687161 |
| PMID | 38830798 |
| MeSH | Animals Antigens, Surface* / genetics Antigens, Surface* / metabolism Apoptosis / drug effects Efferocytosis Glucosides* / pharmacology Humans Macrophages* / drug effects Macrophages* / metabolism Mice Milk Proteins Phagocytosis* / drug effects Resveratrol* / pharmacology Stilbenes / pharmacology THP-1 Cells |
| IF | 1.516 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | Jurkat |