論文 - 詳細
| RRC ID | 81333 |
|---|---|
| 著者 | Haedar JR, Uria AR, Lallo S, Dibwe DF, Wakimoto T. |
| タイトル | New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents. |
| ジャーナル | Mar Drugs |
| Abstract |
We reported three new members of the theonellapeptolide family from theonellapeptolide II series, namely theonellapeptolides IIb (1), IIa (2), IIc (3), and three known members-IId (4), IIe (5), and Id (6)-from Kodingarengan marine sponge Theonella swinhoei collected in Makassar, Indonesia. The structures of tridecadepsipeptides 1-3, including the absolute configurations of their amino acids, were determined by the integrated NMR and tandem MS analyses followed by Marfey's analysis. To the best of our knowledge, 1 and 2 are the first theonellapeptolide-type compounds to have a valine residue with D configuration at residue position 6. The isolated theonellapeptolide-type compounds 1-6 showed selective cytotoxic activity against human pancreatic MIA PaCa-2 cancer cells in a nutrient-deprived medium. Among them, the most potent preferential cytotoxicity was observed in new theonellapeptolide IIc (3) and known IId (4), IIe (5), and Id (6). |
| 巻・号 | 20(11) |
| 公開日 | 2022-10-25 |
| DOI | 10.3390/md20110661 |
| PII | md20110661 |
| PMID | 36354984 |
| PMC | PMC9697519 |
| MeSH | Animals Antineoplastic Agents* / pharmacology Humans Indonesia Magnetic Resonance Spectroscopy Molecular Structure Theonella* / chemistry |
| IF | 4.073 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MIA Paca2(RCB2094) |