論文 - 詳細
| RRC ID | 81418 |
|---|---|
| 著者 | Pedroni A, Dai YE, Lafouasse L, Chang W, Srivastava I, Del Vecchio L, Ampatzis K. |
| タイトル | Neuroprotective gap-junction-mediated bystander transformations in the adult zebrafish spinal cord after injury. |
| ジャーナル | Nat Commun |
| Abstract |
The adult zebrafish spinal cord displays an impressive innate ability to regenerate after traumatic insults, yet the underlying adaptive cellular mechanisms remain elusive. Here, we show that while the cellular and tissue responses after injury are largely conserved among vertebrates, the large-size fast spinal zebrafish motoneurons are remarkably resilient by remaining viable and functional. We also reveal the dynamic changes in motoneuron glutamatergic input, excitability, and calcium signaling, and we underscore the critical role of calretinin (CR) in binding and buffering the intracellular calcium after injury. Importantly, we demonstrate the presence and the dynamics of a neuron-to-neuron bystander neuroprotective biochemical cooperation mediated through gap junction channels. Our findings support a model in which the intimate and dynamic interplay between glutamate signaling, calcium buffering, gap junction channels, and intercellular cooperation upholds cell survival and promotes the initiation of regeneration. |
| 巻・号 | 15(1) |
| ページ | 4331 |
| 公開日 | 2024-5-21 |
| DOI | 10.1038/s41467-024-48729-9 |
| PII | 10.1038/s41467-024-48729-9 |
| PMID | 38773121 |
| PMC | PMC11109231 |
| MeSH | Animals Calbindin 2 / metabolism Calcium / metabolism Calcium Signaling Cell Survival Gap Junctions* / metabolism Glutamic Acid / metabolism Motor Neurons* / metabolism Spinal Cord* / metabolism Spinal Cord Injuries* / metabolism Zebrafish* Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 37 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(chx10:GFP) |