| RRC ID |
81466
|
| 著者 |
Hiraiwa S, Takeshita S, Terano T, Hayashi R, Suzuki K, Tajiri R, Kojima T.
|
| タイトル |
Unveiling the cell dynamics during the final shape formation of the tarsus in Drosophila adult leg by live imaging.
|
| ジャーナル |
Dev Genes Evol
|
| Abstract |
Organisms display a remarkable diversity in their shapes. Although substantial progress has been made in unraveling the mechanisms that govern cell fate determination during development, the mechanisms by which fate-determined cells give rise to the final shapes of organisms remain largely unknown. This study describes in detail the process of the final shape formation of the tarsus, which is near the distal tip of the adult leg, during the pupal stage in Drosophila melanogaster. Days-long live imaging revealed unexpectedly complicated cellular dynamics. The epithelial cells transiently form the intriguing structure, which we named the Parthenon-like structure. The basal surface of the epithelial cells and localization of the basement membrane protein initially show a mesh-like structure and rapidly shrink into the membranous structure during the formation and disappearance of the Parthenon-like structure. Furthermore, macrophage-like cells are observed moving around actively in the Parthenon-like structure and engulfing epithelial cells. The findings in this research are expected to significantly contribute to our understanding of the mechanisms involved in shaping the final structure of the adult tarsus.
|
| 公開日 |
2024-7-8
|
| DOI |
10.1007/s00427-024-00719-z
|
| PII |
10.1007/s00427-024-00719-z
|
| PMID |
38977431
|
| PMC |
PMC11611951
|
| MeSH |
Animals
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
Drosophila melanogaster* / cytology
Drosophila melanogaster* / growth & development
Epithelial Cells / cytology
Epithelial Cells / metabolism
Pupa / cytology
Pupa / growth & development
Tarsus, Animal / growth & development
|
| IF |
1.339
|
| リソース情報 |
| ショウジョウバエ |
DGRC#109667 |
