論文 - 詳細
| RRC ID | 81479 |
|---|---|
| 著者 | Sekine S, Tarama M, Wada H, Sami MM, Shibata T, Hayashi S. |
| タイトル | Emergence of periodic circumferential actin cables from the anisotropic fusion of actin nanoclusters during tubulogenesis. |
| ジャーナル | Nat Commun |
| Abstract |
The periodic circumferential cytoskeleton supports various tubular tissues. Radial expansion of the tube lumen causes anisotropic tensile stress, which can be exploited as a geometric cue. However, the molecular machinery linking anisotropy to robust circumferential patterning is poorly understood. Here, we aim to reveal the emergent process of circumferential actin cable formation in a Drosophila tracheal tube. During luminal expansion, sporadic actin nanoclusters emerge and exhibit circumferentially biased motion and fusion. RNAi screening reveals the formin family protein, DAAM, as an essential component responding to tissue anisotropy, and non-muscle myosin II as a component required for nanocluster fusion. An agent-based model simulation suggests that crosslinkers play a crucial role in nanocluster formation and cluster-to-cable transition occurs in response to mechanical anisotropy. Altogether, we propose that an actin nanocluster is an organizational unit that responds to stress in the cortical membrane and builds a higher-order cable structure. |
| 巻・号 | 15(1) |
| ページ | 464 |
| 公開日 | 2024-1-24 |
| DOI | 10.1038/s41467-023-44684-z |
| PII | 10.1038/s41467-023-44684-z |
| PMID | 38267421 |
| PMC | PMC10808230 |
| MeSH | Actins* Adaptor Proteins, Signal Transducing Animals Anisotropy Computer Simulation Cytoskeleton Drosophila Drosophila Proteins* / genetics Margins of Excision |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 36 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#107829 DGRC#119606 DGRC#119607 DGRC#119608 |