Reference - Detail
| RRC ID | 81483 |
|---|---|
| Author | Fioriti F, Rifflet A, Gomperts Boneca I, Zugasti O, Royet J. |
| Title | Bacterial peptidoglycan serves as a critical modulator of the gut-immune-brain axis in Drosophila. |
| Journal | Brain Behav Immun |
| Abstract |
Metabolites and compounds derived from gut-associated bacteria can modulate numerous physiological processes in the host, including immunity and behavior. Using a model of oral bacterial infection, we previously demonstrated that gut-derived peptidoglycan (PGN), an essential constituent of the bacterial cell envelope, influences female fruit fly egg-laying behavior by activating the NF-κB cascade in a subset of brain neurons. These findings underscore PGN as a potential mediator of communication between gut bacteria and the brain in Drosophila, prompting further investigation into its impact on all brain cells. Through high-resolution mass spectrometry, we now show that PGN fragments produced by gut bacteria can rapidly reach the central nervous system. In Addition, by employing a combination of whole-genome transcriptome analyses, comprehensive genetic assays, and reporter gene systems, we reveal that gut bacterial infection triggers a PGN dose-dependent NF-κB immune response in perineurial glia, forming the continuous outer cell layer of the blood-brain barrier. Furthermore, we demonstrate that persistent PGN-dependent NF-κB activation in perineurial glial cells correlates with a reduction in lifespan and early neurological decline. Overall, our findings establish gut-derived PGN as a critical mediator of the gut-immune-brain axis in Drosophila. |
| Volume | 119 |
| Pages | 878-897 |
| Published | 2024-7-1 |
| DOI | 10.1016/j.bbi.2024.05.009 |
| PII | S0889-1591(24)00398-2 |
| PMID | 38710338 |
| MeSH | Animals Blood-Brain Barrier / immunology Blood-Brain Barrier / metabolism Brain* / immunology Brain* / metabolism Brain-Gut Axis* / physiology Drosophila Drosophila Proteins / metabolism Drosophila melanogaster / metabolism Female Gastrointestinal Microbiome* / physiology NF-kappa B* / metabolism Neuroglia / immunology Neuroglia / metabolism Neurons / metabolism Peptidoglycan* / metabolism |
| IF | 6.633 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#103953 DGRC#105240 DGRC#112830 DGRC#103953 |