Reference - Detail
| RRC ID | 81486 |
|---|---|
| Author | Ridwan SM, Twillie A, Poursaeid S, Beard EK, Bener MB, Antel M, Cowan AE, Matsuda S, Inaba M. |
| Title | Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation. |
| Journal | Nat Commun |
| Abstract |
Drosophila male germline stem cells (GSCs) reside at the tip of the testis and surround a cluster of niche cells. Decapentaplegic (Dpp) is one of the well-established ligands and has a major role in maintaining stem cells located in close proximity. However, the existence and the role of the diffusible fraction of Dpp outside of the niche have been unclear. Here, using genetically-encoded nanobodies called Morphotraps, we physically block Dpp diffusion without interfering with niche-stem cell signaling and find that a diffusible fraction of Dpp is required to ensure differentiation of GSC daughter cells, opposite of its role in maintenance of GSC in the niche. Our work provides an example in which a soluble niche ligand induces opposed cellular responses in stem cells versus in differentiating descendants to ensure spatial control of the niche. This may be a common mechanism to regulate tissue homeostasis. |
| Volume | 15(1) |
| Pages | 1166 |
| Published | 2024-2-7 |
| DOI | 10.1038/s41467-024-45408-7 |
| PII | 10.1038/s41467-024-45408-7 |
| PMID | 38326318 |
| PMC | PMC10850516 |
| MeSH | Animals Cell Differentiation / physiology Drosophila / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Germ Cells / metabolism Ligands Male Signal Transduction / physiology Stem Cell Niche / physiology |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 12 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#103948 |