| RRC ID |
81488
|
| 著者 |
Lee JY, Gala DS, Kiourlappou M, Olivares-Abril J, Joha J, Titlow JS, Teodoro RO, Davis I.
|
| タイトル |
Murine glial protrusion transcripts predict localized Drosophila glial mRNAs involved in plasticity.
|
| ジャーナル |
J Cell Biol
|
| Abstract |
The polarization of cells often involves the transport of specific mRNAs and their localized translation in distal projections. Neurons and glia are both known to contain long cytoplasmic processes, while localized transcripts have only been studied extensively in neurons, not glia, especially in intact nervous systems. Here, we predict 1,740 localized Drosophila glial transcripts by extrapolating from our meta-analysis of seven existing studies characterizing the localized transcriptomes and translatomes of synaptically associated mammalian glia. We demonstrate that the localization of mRNAs in mammalian glial projections strongly predicts the localization of their high-confidence Drosophila homologs in larval motor neuron-associated glial projections and are highly statistically enriched for genes associated with neurological diseases. We further show that some of these localized glial transcripts are specifically required in glia for structural plasticity at the nearby neuromuscular junction synapses. We conclude that peripheral glial mRNA localization is a common and conserved phenomenon and propose that it is likely to be functionally important in disease.
|
| 巻・号 |
223(10)
|
| 公開日 |
2024-10-7
|
| DOI |
10.1083/jcb.202306152
|
| PII |
276869
|
| PMID |
39037431
|
| PMC |
PMC11262410
|
| MeSH |
Animals
Drosophila / genetics
Drosophila / metabolism
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
Drosophila melanogaster / genetics
Drosophila melanogaster / metabolism
Mice
Motor Neurons / metabolism
Neuroglia* / metabolism
Neuromuscular Junction* / genetics
Neuromuscular Junction* / metabolism
Neuronal Plasticity* / genetics
RNA, Messenger* / genetics
RNA, Messenger* / metabolism
Transcriptome / genetics
|
| IF |
8.811
|
| リソース情報 |
| ショウジョウバエ |
DGRC#115163
DGRC#115165
DGRC#115188
DGRC#115291
DGRC#115314
DGRC#115323
DGRC#115397
DGRC#115528
DGRC#115547
DGRC#115558 |
