論文 - 詳細
| RRC ID | 81488 |
|---|---|
| 著者 | Lee JY, Gala DS, Kiourlappou M, Olivares-Abril J, Joha J, Titlow JS, Teodoro RO, Davis I. |
| タイトル | Murine glial protrusion transcripts predict localized Drosophila glial mRNAs involved in plasticity. |
| ジャーナル | J Cell Biol |
| Abstract |
The polarization of cells often involves the transport of specific mRNAs and their localized translation in distal projections. Neurons and glia are both known to contain long cytoplasmic processes, while localized transcripts have only been studied extensively in neurons, not glia, especially in intact nervous systems. Here, we predict 1,740 localized Drosophila glial transcripts by extrapolating from our meta-analysis of seven existing studies characterizing the localized transcriptomes and translatomes of synaptically associated mammalian glia. We demonstrate that the localization of mRNAs in mammalian glial projections strongly predicts the localization of their high-confidence Drosophila homologs in larval motor neuron-associated glial projections and are highly statistically enriched for genes associated with neurological diseases. We further show that some of these localized glial transcripts are specifically required in glia for structural plasticity at the nearby neuromuscular junction synapses. We conclude that peripheral glial mRNA localization is a common and conserved phenomenon and propose that it is likely to be functionally important in disease. |
| 巻・号 | 223(10) |
| 公開日 | 2024-10-7 |
| DOI | 10.1083/jcb.202306152 |
| PII | 276869 |
| PMID | 39037431 |
| PMC | PMC11262410 |
| MeSH | Animals Drosophila / genetics Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Mice Motor Neurons / metabolism Neuroglia* / metabolism Neuromuscular Junction* / genetics Neuromuscular Junction* / metabolism Neuronal Plasticity* / genetics RNA, Messenger* / genetics RNA, Messenger* / metabolism Transcriptome / genetics |
| IF | 8.811 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#115163 DGRC#115165 DGRC#115188 DGRC#115291 DGRC#115314 DGRC#115323 DGRC#115397 DGRC#115528 DGRC#115547 DGRC#115558 |