論文 - 詳細
| RRC ID | 81498 |
|---|---|
| 著者 | Nakamura M, Parkhurst SM. |
| タイトル | Calcium influx rapidly establishes distinct spatial recruitments of Annexins to cell wounds. |
| ジャーナル | Genetics |
| Abstract |
To survive daily damage, the formation of actomyosin ring at the wound edge is required to rapidly close cell wounds. Calcium influx is one of the start signals for these cell wound repair events. Here, we find that the rapid recruitment of all 3 Drosophila calcium-responding and phospholipid-binding Annexin proteins (AnxB9, AnxB10, and AnxB11) to distinct regions around the wound is regulated by the quantity of calcium influx rather than their binding to specific phospholipids. The distinct recruitment patterns of these Annexins regulate the subsequent recruitment of RhoGEF2 and RhoGEF3 through actin stabilization to form a robust actomyosin ring. Surprisingly, while the wound does not close in the absence of calcium influx, we find that reduced calcium influx can still initiate repair processes, albeit leading to severe repair phenotypes. Thus, our results suggest that, in addition to initiating repair events, the quantity of calcium influx is important for precise Annexin spatiotemporal protein recruitment to cell wounds and efficient wound repair. |
| 巻・号 | 227(4) |
| 公開日 | 2024-8-7 |
| DOI | 10.1093/genetics/iyae101 |
| PII | 7693402 |
| PMID | 38874345 |
| PMC | PMC11304956 |
| MeSH | Actins / genetics Actins / metabolism Actomyosin / metabolism Animals Annexins* / genetics Annexins* / metabolism Calcium* / metabolism Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Wound Healing* |
| IF | 4.015 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#109855 |