論文 - 詳細
| RRC ID | 81499 |
|---|---|
| 著者 | Roach TV, Lenhart KF. |
| タイトル | Mating-induced Ecdysone in the testis disrupts soma-germline contacts and stem cell cytokinesis. |
| ジャーナル | Development |
| Abstract |
Germline maintenance relies on adult stem cells to continually replenish lost gametes over a lifetime and respond to external cues altering the demands on the tissue. Mating worsens germline homeostasis over time, yet a negative impact on stem cell behavior has not been explored. Using extended live imaging of the Drosophila testis stem cell niche, we find that short periods of mating in young males disrupts cytokinesis in germline stem cells (GSCs). This defect leads to failure of abscission, preventing release of differentiating cells from the niche. We find that GSC abscission failure is caused by increased Ecdysone hormone signaling induced upon mating, which leads to disrupted somatic encystment of the germline. Abscission failure is rescued by isolating males from females, but recurs with resumption of mating. Importantly, reiterative mating also leads to increased GSC loss, requiring increased restoration of stem cells via symmetric renewal and de-differentiation. Together, these results suggest a model whereby acute mating results in hormonal changes that negatively impact GSC cytokinesis but preserves the stem cell population. |
| 巻・号 | 151(11) |
| 公開日 | 2024-6-1 |
| DOI | 10.1242/dev.202542 |
| PII | 352281 |
| PMID | 38832826 |
| PMC | PMC11190578 |
| MeSH | Animals Cell Differentiation Cytokinesis* Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster* / metabolism Ecdysone* / metabolism Female Germ Cells* / cytology Germ Cells* / metabolism Male Signal Transduction Stem Cell Niche Stem Cells / cytology Stem Cells / metabolism Testis* / metabolism |
| IF | 5.611 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104055 |