論文 - 詳細
| RRC ID | 81503 |
|---|---|
| 著者 | He L, Sun F, Wu Y, Li Z, Fu Y, Huang Q, Li J, Wang Z, Cai J, Feng C, Deng X, Gu H, He X, Yu J, Sun F. |
| タイトル | L(1)10Bb serves as a conservative determinant for soma-germline communications via cellular non-autonomous effects within the testicular stem cell niche. |
| ジャーナル | Mol Cell Endocrinol |
| Abstract |
The testicular stem cell niche is the central regulator of spermatogenesis in Drosophila melanogaster. However, the underlying regulatory mechanisms are unclear. This study demonstrated the crucial role of lethal (1) 10Bb [l(1)10Bb] in regulating the testicular stem cell niche. Dysfunction of l(1)10Bb in early-stage cyst cells led to male fertility disorders and compromised cyst stem cell maintenance. Moreover, the dysfunction of l(1)10Bb in early-stage cyst cells exerted non-autonomous effects on germline stem cell differentiation, independently of hub signals. Notably, our study highlights the rescue of testicular defects through ectopic expression of L(1)10Bb and the human homologous protein BUD31 homolog (BUD31). In addition, l(1)10Bb dysfunction in early-stage cyst cells downregulated the expression of spliceosome subunits in the Sm and the precursor RNA processing complexes. Collectively, our findings established l(1)10Bb as a pivotal factor in the modulation of Drosophila soma-germline communications within the testicular stem cell niche. |
| 巻・号 | 591 |
| ページ | 112278 |
| 公開日 | 2024-9-15 |
| DOI | 10.1016/j.mce.2024.112278 |
| PII | S0303-7207(24)00134-5 |
| PMID | 38795826 |
| MeSH | Animals Cell Communication Cell Differentiation Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster* / genetics Drosophila melanogaster* / metabolism Genes, Lethal Germ Cells / cytology Germ Cells / metabolism Humans Male Spermatogenesis Spliceosomes / metabolism Stem Cell Niche* Stem Cells / cytology Stem Cells / metabolism Testis / cytology Testis / metabolism |
| IF | 3.871 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#104055 |