論文 - 詳細
| RRC ID | 81510 |
|---|---|
| 著者 | Takuma Ariizumi, Koshiro Tabata, Yukari Itakura, Hiroko Kobayashi, William W. Hall, Michihito Sasaki, Hirofumi Sawa, Keita Matsuno, Yasuko Orba |
| タイトル | Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections |
| ジャーナル | PLOS Pathogens |
| Abstract |
Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment. |
| 巻・号 | 20 |
| ページ | e1012101 |
| 公開日 | 2024-3-19 |
| DOI | 10.1371/journal.ppat.1012101 |
| PMID | 38502642 |
| PMC | PMC10980201 |
| MeSH | Animals Antiviral Agents / pharmacology Antiviral Agents / therapeutic use Disease Models, Animal Mice Mice, Knockout Nairovirus* Tick-Borne Diseases* |
| IF | 6.218 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| ヒト病原ウイルス | orthonairoviruses |