| RRC ID |
81510
|
| Author |
Takuma Ariizumi, Koshiro Tabata, Yukari Itakura, Hiroko Kobayashi, William W. Hall, Michihito Sasaki, Hirofumi Sawa, Keita Matsuno, Yasuko Orba
|
| Title |
Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections
|
| Journal |
PLOS Pathogens
|
| Abstract |
Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment.
|
| Volume |
20
|
| Pages |
e1012101
|
| Published |
2024-3-19
|
| DOI |
10.1371/journal.ppat.1012101
|
| PMID |
38502642
|
| PMC |
PMC10980201
|
| MeSH |
Animals
Antiviral Agents / pharmacology
Antiviral Agents / therapeutic use
Disease Models, Animal
Mice
Mice, Knockout
Nairovirus*
Tick-Borne Diseases*
|
| IF |
6.218
|
| Resource |
| Human pathogenic viruses |
orthonairoviruses |
