論文 - 詳細
| RRC ID | 81583 |
|---|---|
| 著者 | Santoni G, Astori S, Leleu M, Glauser L, Zamora SA, Schioppa M, Tarulli I, Sandi C, Gräff J. |
| タイトル | Chromatin plasticity predetermines neuronal eligibility for memory trace formation. |
| ジャーナル | Science |
| Abstract |
Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron's eligibility to be recruited into the memory trace depends on its epigenetic state prior to encoding. Principal neurons in the mouse lateral amygdala display intrinsic chromatin plasticity, which when experimentally elevated favors neuronal allocation into the encoding ensemble. Such chromatin plasticity occurred at genomic regions underlying synaptic plasticity and was accompanied by increased neuronal excitability in single neurons in real time. Lastly, optogenetic silencing of the epigenetically altered neurons prevented memory expression, revealing a cell-autonomous relationship between chromatin plasticity and memory trace formation. These results identify the epigenetic state of a neuron as a key factor enabling information encoding. |
| 巻・号 | 385(6707) |
| ページ | eadg9982 |
| 公開日 | 2024-7-26 |
| DOI | 10.1126/science.adg9982 |
| PMID | 39052786 |
| MeSH | Amygdala / physiology Animals Chromatin* / metabolism Epigenesis, Genetic* Male Memory* / physiology Mice Mice, Inbred C57BL Neuronal Plasticity* Neurons* / physiology Optogenetics |
| IF | 41.846 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 305 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.5 |
| リソース情報 | |
| 遺伝子材料 | pcDNA3.1(+)-Histac-H3K9/K14 (RDB14340) Histac pcDNA3.1 (RDB12840) |