| RRC ID |
81583
|
| 著者 |
Santoni G, Astori S, Leleu M, Glauser L, Zamora SA, Schioppa M, Tarulli I, Sandi C, Gräff J.
|
| タイトル |
Chromatin plasticity predetermines neuronal eligibility for memory trace formation.
|
| ジャーナル |
Science
|
| Abstract |
Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron's eligibility to be recruited into the memory trace depends on its epigenetic state prior to encoding. Principal neurons in the mouse lateral amygdala display intrinsic chromatin plasticity, which when experimentally elevated favors neuronal allocation into the encoding ensemble. Such chromatin plasticity occurred at genomic regions underlying synaptic plasticity and was accompanied by increased neuronal excitability in single neurons in real time. Lastly, optogenetic silencing of the epigenetically altered neurons prevented memory expression, revealing a cell-autonomous relationship between chromatin plasticity and memory trace formation. These results identify the epigenetic state of a neuron as a key factor enabling information encoding.
|
| 巻・号 |
385(6707)
|
| ページ |
eadg9982
|
| 公開日 |
2024-7-26
|
| DOI |
10.1126/science.adg9982
|
| PMID |
39052786
|
| MeSH |
Amygdala / physiology
Animals
Chromatin* / metabolism
Epigenesis, Genetic*
Male
Memory* / physiology
Mice
Mice, Inbred C57BL
Neuronal Plasticity*
Neurons* / physiology
Optogenetics
|
| IF |
41.846
|
| リソース情報 |
| 遺伝子材料 |
pcDNA3.1(+)-Histac-H3K9/K14 (RDB14340)
Histac pcDNA3.1 (RDB12840) |
