RRC ID 81612
Author Gan Z, Fang X, Yin C, Tian Y, Zhang L, Zhong X, Jiang G, Tao A.
Title Extraction, purification, structural characterization, and bioactivities of the genus Rhodiola L. polysaccharides: A review.
Journal Int J Biol Macromol
Abstract The genus Rhodiola L., an integral part of traditional Chinese medicine and Tibetan medicine in China, exhibits a broad spectrum of applications. This genus contains key compounds such as ginsenosides, polysaccharides, and flavonoids, which possess anti-inflammatory, antioxidant, hypoglycaemic, immune-enhancing, and anti-hypoxic properties. As a vital raw material, Rhodiola L. contributes to twenty-four kinds of Chinese patent medicines and 481 health food products in China, finding extensive application in the health food sector. Recently, polysaccharides have emerged as a focal point in natural product research, with applications spanning the medicine, food, and materials sectors. Despite this, a comprehensive and systematic review of polysaccharides from the genus Rhodiola L. polysaccharides (TGRPs) is warranted. This study undertakes a systematic review of both domestic and international literature, assessing the research advancements and chemical functional values of polysaccharides derived from Rhodiola rosea. It involves the isolation, purification, and identification of a variety of homogeneous polysaccharides, followed by a detailed analysis of their chemical structures, pharmacological activities, and molecular mechanisms, structure-activity relationship (SAR) of TGRPs. The discussion includes the influence of molecular weight, monosaccharide composition, and glycosidic bonds on their biological activities, such as sulfation and carboxymethylation et al. Such analyses are crucial for deepening the understanding of Rhodiola rosea and for fostering the development and exploitation of TGRPs, offering a reference point for further investigations into TGRPs and their resource utilization.
Volume 276(Pt 1)
Pages 133614
Published 2024-7-1
DOI 10.1016/j.ijbiomac.2024.133614
PII S0141-8130(24)04419-2
PMID 38960222
MeSH Anti-Inflammatory Agents / chemistry Anti-Inflammatory Agents / isolation & purification Anti-Inflammatory Agents / pharmacology Antioxidants / chemistry Antioxidants / isolation & purification Antioxidants / pharmacology Molecular Weight Monosaccharides / analysis Monosaccharides / chemistry Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology Polysaccharides* / chemistry Polysaccharides* / isolation & purification Polysaccharides* / pharmacology Rhodiola* / chemistry Structure-Activity Relationship
Resource
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