論文 - 詳細
| RRC ID | 81681 |
|---|---|
| 著者 | Hu X, Roy SR, Jin C, Li G, Zhang Q, Asano N, Asahina S, Kajiwara T, Takahara A, Feng B, Aoki K, Xu C, Zhang Y. |
| タイトル | Control cell migration by engineering integrin ligand assembly. |
| ジャーナル | Nat Commun |
| Abstract |
Advances in mechanistic understanding of integrin-mediated adhesion highlight the importance of precise control of ligand presentation in directing cell migration. Top-down nanopatterning limited the spatial presentation to sub-micron placing restrictions on both fundamental study and biomedical applications. To break the constraint, here we propose a bottom-up nanofabrication strategy to enhance the spatial resolution to the molecular level using simple formulation that is applicable as treatment agent. Via self-assembly and co-assembly, precise control of ligand presentation is succeeded by varying the proportions of assembling ligand and nonfunctional peptide. Assembled nanofilaments fulfill multi-functions exerting enhancement to suppression effect on cell migration with tunable amplitudes. Self-assembled nanofilaments possessing by far the highest ligand density prevent integrin/actin disassembly at cell rear, which expands the perspective of ligand-density-dependent-modulation, revealing valuable inputs to therapeutic innovations in tumor metastasis. |
| 巻・号 | 13(1) |
| ページ | 5002 |
| 公開日 | 2022-8-25 |
| DOI | 10.1038/s41467-022-32686-2 |
| PII | 10.1038/s41467-022-32686-2 |
| PMID | 36008449 |
| PMC | PMC9411606 |
| MeSH | Cell Adhesion / physiology Cell Movement / physiology Integrins* / metabolism Ligands Protein Binding |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HuH-7(RCB1366) Hep G2(RCB1886) MKN1(RCB1003) MCF7(RCB1904) HeLa(RCB0007) |