RRC ID 81682
Author Iannone AF, Akgül G, Zhang R, Wacks S, Hussein N, Macias CG, Donatelle A, Bauriedel JMJ, Wright C, Abramov D, Johnson MA, Govek EE, Burré J, Milner TA, De Marco García NV.
Title The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex.
Journal Cell Rep
Abstract Spontaneous and sensory-evoked activity sculpts developing circuits. Yet, how these activity patterns intersect with cellular programs regulating the differentiation of neuronal subtypes is not well understood. Through electrophysiological and in vivo longitudinal analyses, we show that C-X-C motif chemokine ligand 14 (Cxcl14), a gene previously characterized for its association with tumor invasion, is expressed by single-bouquet cells (SBCs) in layer I (LI) of the somatosensory cortex during development. Sensory deprivation at neonatal stages markedly decreases Cxcl14 expression. Additionally, we report that loss of function of this gene leads to increased intrinsic excitability of SBCs-but not LI neurogliaform cells-and augments neuronal complexity. Furthermore, Cxcl14 loss impairs sensory map formation and compromises the in vivo recruitment of superficial interneurons by sensory inputs. These results indicate that Cxcl14 is required for LI differentiation and demonstrate the emergent role of chemokines as key players in cortical network development.
Volume 43(8)
Pages 114531
Published 2024-8-27
DOI 10.1016/j.celrep.2024.114531
PII S2211-1247(24)00860-X
PMID 39058591
PMC PMC11373301
MeSH Animals Cell Differentiation* Chemokines, CXC* / genetics Chemokines, CXC* / metabolism Interneurons* / metabolism Mice Mice, Inbred C57BL Somatosensory Cortex* / cytology Somatosensory Cortex* / metabolism
Resource
Mice RBRC02308