論文 - 詳細
| RRC ID | 81710 |
|---|---|
| 著者 | Takase M, Imamura T, Sampath TK, Takeda K, Ichijo H, Miyazono K, Kawabata M. |
| タイトル | Induction of Smad6 mRNA by bone morphogenetic proteins. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Members of the transforming growth factor-beta (TGF-beta) superfamily transduce signals via Smad proteins. Smad2 and Smad3 mediate TGF-beta signaling, whereas Smad1 and Smad5 transduce bone morphogenetic protein (BMP) signals. Smad4 is a common mediator required for both pathways. Smad6 and Smad7 are recently identified members in the Smad family; they inhibit the signaling activity of the other Smad proteins. Here we show that expression of the Smad6 mRNA is dramatically induced by BMP-2 or osteogenic protein-1 (OP-1)/BMP-7 in various cells. BMP-2 induced expression of Smad7 in one cell type, although much less potently than that of Smad6. Smad6 message was induced by TGF-beta 1 in TGF-beta 1-responsive Mv1Lu cells, but the induction was transient in contrast to the induction by BMPs. These results indicate that Smad6 may form a feedback loop to regulate the signaling activity of BMPs. |
| 巻・号 | 244(1) |
| ページ | 26-9 |
| 公開日 | 1998-3-6 |
| DOI | 10.1006/bbrc.1998.8200 |
| PII | S0006-291X(98)98200-6 |
| PMID | 9514869 |
| MeSH | Animals Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins / pharmacology* CHO Cells Cell Line Cricetinae DNA-Binding Proteins / biosynthesis* DNA-Binding Proteins / drug effects DNA-Binding Proteins / genetics* Gene Expression Regulation / drug effects Humans Ligands Lung Mice Mice, Inbred C3H Mink RNA, Messenger / biosynthesis* RNA, Messenger / drug effects Smad6 Protein Trans-Activators* Transforming Growth Factor beta / pharmacology |
| IF | 2.985 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ST2(RCB0224) |