| RRC ID |
81710
|
| 著者 |
Takase M, Imamura T, Sampath TK, Takeda K, Ichijo H, Miyazono K, Kawabata M.
|
| タイトル |
Induction of Smad6 mRNA by bone morphogenetic proteins.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Members of the transforming growth factor-beta (TGF-beta) superfamily transduce signals via Smad proteins. Smad2 and Smad3 mediate TGF-beta signaling, whereas Smad1 and Smad5 transduce bone morphogenetic protein (BMP) signals. Smad4 is a common mediator required for both pathways. Smad6 and Smad7 are recently identified members in the Smad family; they inhibit the signaling activity of the other Smad proteins. Here we show that expression of the Smad6 mRNA is dramatically induced by BMP-2 or osteogenic protein-1 (OP-1)/BMP-7 in various cells. BMP-2 induced expression of Smad7 in one cell type, although much less potently than that of Smad6. Smad6 message was induced by TGF-beta 1 in TGF-beta 1-responsive Mv1Lu cells, but the induction was transient in contrast to the induction by BMPs. These results indicate that Smad6 may form a feedback loop to regulate the signaling activity of BMPs.
|
| 巻・号 |
244(1)
|
| ページ |
26-9
|
| 公開日 |
1998-3-6
|
| DOI |
10.1006/bbrc.1998.8200
|
| PII |
S0006-291X(98)98200-6
|
| PMID |
9514869
|
| MeSH |
Animals
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins / pharmacology*
CHO Cells
Cell Line
Cricetinae
DNA-Binding Proteins / biosynthesis*
DNA-Binding Proteins / drug effects
DNA-Binding Proteins / genetics*
Gene Expression Regulation / drug effects
Humans
Ligands
Lung
Mice
Mice, Inbred C3H
Mink
RNA, Messenger / biosynthesis*
RNA, Messenger / drug effects
Smad6 Protein
Trans-Activators*
Transforming Growth Factor beta / pharmacology
|
| IF |
2.985
|
| リソース情報 |
| ヒト・動物細胞 |
ST2(RCB0224) |
