RRC ID 81802
Author Jeyarajah MJ, Patterson VS, Jaju Bhattad G, Zhao L, Whitehead SN, Renaud SJ.
Title Placental extracellular vesicles promote cardiomyocyte maturation and fetal heart development.
Journal Commun Biol
Abstract Congenital heart defects are leading causes of neonatal mortality and are often associated with placental abnormalities, but mechanisms linking placenta and heart development are poorly understood. Herein, we investigated a potential signaling network connecting the placenta and nascent heart in mice. We found that fetal hearts exposed to media conditioned by placental tissue or differentiated wild-type trophoblast stem (TS) cells, but not undifferentiated TS cells, showed increased heart rate and epicardial cell outgrowth. This effect was not observed when hearts were exposed to media from TS cells lacking OVO-Like 2, a transcription factor required for trophoblast differentiation and placental development. Trophoblasts released abundant extracellular vesicles into media, and these vesicles were sufficient to mediate cardio-promoting effects. Our findings provide a potential mechanism whereby the placenta communicates with the fetal heart to promote cardiac morphogenesis, and offers insight into the link between poor placentation and a higher incidence of heart defects.
Volume 7(1)
Pages 1254
Published 2024-10-3
DOI 10.1038/s42003-024-06938-4
PII 10.1038/s42003-024-06938-4
PMID 39363116
PMC PMC11450004
MeSH Animals Cell Differentiation Extracellular Vesicles* / metabolism Female Fetal Heart / embryology Fetal Heart / metabolism Mice Mice, Inbred C57BL Myocytes, Cardiac* / metabolism Placenta* / metabolism Pregnancy Trophoblasts / metabolism
Resource
Mice RBRC02891