論文 - 詳細
| RRC ID | 81894 |
|---|---|
| 著者 | Yonemura A, Semba T, Zhang J, Fan Y, Yasuda-Yoshihara N, Wang H, Uchihara T, Yasuda T, Nishimura A, Fu L, Hu X, Wei F, Kitamura F, Akiyama T, Yamashita K, Eto K, Iwagami S, Iwatsuki M, Miyamoto Y, Matsusaki K, Yamasaki J, Nagano O, Saya H, Song S, Tan P, Baba H, Ajani JA, Ishimoto T. |
| タイトル | Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment. |
| ジャーナル | Cell Rep |
| Abstract |
Malignant ascites accompanied by peritoneal dissemination contain various factors and cell populations as well as cancer cells; however, how the tumor microenvironment is shaped in ascites remains unclear. Single-cell proteomic profiling and a comprehensive proteomic analysis are conducted to comprehensively characterize malignant ascites. Here, we find defects in immune effectors along with immunosuppressive cell accumulation in ascites of patients with gastric cancer (GC) and identify five distinct subpopulations of CD45(-)/EpCAM(-) cells. Mesothelial cells with mesenchymal features in CD45(-)/EpCAM(-) cells are the predominant source of chemokines involved in immunosuppressive myeloid cell (IMC) recruitment. Moreover, mesothelial-mesenchymal transition (MMT)-induced mesothelial cells strongly express extracellular matrix (ECM)-related genes, including tenascin-C (TNC), enhancing metastatic colonization. These findings highlight the definite roles of the mesenchymal cell population in the development of a protumorigenic microenvironment to promote peritoneal dissemination. |
| 巻・号 | 43(1) |
| ページ | 113613 |
| 公開日 | 2024-1-23 |
| DOI | 10.1016/j.celrep.2023.113613 |
| PII | S2211-1247(23)01625-X |
| PMID | 38232734 |
| MeSH | Ascites* / pathology Cell Line, Tumor Epithelial Cell Adhesion Molecule Humans Peritoneal Neoplasms* / pathology Peritoneum / pathology Proteomics Tumor Microenvironment |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00169 |