論文 - 詳細
| RRC ID | 81956 |
|---|---|
| 著者 | Hung CJ, Ono D, Kilduff TS, Yamanaka A. |
| タイトル | Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy. |
| ジャーナル | Elife |
| Abstract |
Orexin/hypocretin-producing and melanin-concentrating hormone-producing (MCH) neurons are co-extensive in the hypothalamus and project throughout the brain to regulate sleep/wakefulness. Ablation of orexin neurons decreases wakefulness and results in a narcolepsy-like phenotype, whereas ablation of MCH neurons increases wakefulness. Since it is unclear how orexin and MCH neurons interact to regulate sleep/wakefulness, we generated transgenic mice in which both orexin and MCH neurons could be ablated. Double-ablated mice exhibited increased wakefulness and decreased both rapid eye movement (REM) and non-REM (NREM) sleep. Double-ablated mice showed severe cataplexy compared with orexin neuron-ablated mice, suggesting that MCH neurons normally suppress cataplexy. Double-ablated mice also showed frequent sleep attacks with elevated spectral power in the delta and theta range, a unique state that we call 'delta-theta sleep'. Together, these results indicate a functional interaction between orexin and MCH neurons in vivo that suggests the synergistic involvement of these neuronal populations in the sleep/wakefulness cycle. |
| 巻・号 | 9 |
| 公開日 | 2020-4-21 |
| DOI | 10.7554/eLife.54275 |
| PII | 54275 |
| PMID | 32314734 |
| PMC | PMC7173968 |
| MeSH | Animals Cataplexy / metabolism Cataplexy / physiopathology* Hypothalamic Hormones* Melanins* Mice Mice, Transgenic Neurons / physiology* Orexins* Pituitary Hormones* Sleep / physiology* Wakefulness / physiology* |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC05844 |