論文 - 詳細
| RRC ID | 81963 |
|---|---|
| 著者 | Dexiu Yan, Yudai Matsuda |
| タイトル | Methyltransferase Domain‐Focused Genome Mining for Fungal Polyketide Synthases |
| ジャーナル | Small Methods |
| Abstract |
A comparison of substrate‐binding site amino acid residues in the C‐methyltransferase (MT) domains of fungal nonreducing polyketide synthases (NR‐PKSs) suggests that these residues are correlated with the methylation modes used by the PKSs. A PKS, designated as AsbPKS, with substrate‐binding site residues distinct from those of other known PKSs is focused on. The characterization of AsbPKS revealed that it yields an isocoumarin derivative, anhydrosclerotinin B (1), the biosynthesis of which involves a previously unreported methylation pattern. This study demonstrates the utility of MT domain‐focused genome mining for the discovery of PKSs with new functions. |
| 公開日 | 2024-4-21 |
| DOI | 10.1002/smtd.202400107 |
| PMID | 38644685 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原真核微生物 | Aspergillus novofumigatus IFM 55215 |