Reference - Detail
| RRC ID | 82109 |
|---|---|
| Author | Miura A, Narita Y, Sugawara T, Shimizu H, Itoh H. |
| Title | Mizoribine Promotes Molecular Chaperone HSP60/HSP10 Complex Formation. |
| Journal | Int J Mol Sci |
| Abstract |
It has been reported that Mizoribine is an immunosuppressant used to suppress rejection in renal transplantation, nephrotic syndrome, lupus nephritis, and rheumatoid arthritis. The molecular chaperone HSP60 alone induces inflammatory cytokine IL-6 and the co-chaperone HSP10 alone inhibits IL-6 induction. HSP60 and HSP10 form a complex in the presence of ATP. We analyzed the effects of Mizoribine, which is structurally similar to ATP, on the structure and physiological functions of HSP60-HSP10 using Native/PAGE and transmission electron microscopy. At low concentrations of Mizoribine, no complex formation of HSP60-HSP10 was observed, nor was the expression of IL-6 affected. On the other hand, high concentrations of Mizoribine promoted HSP60-HSP10 complex formation and consequently suppressed IL-6 expression. Here, we propose a novel mechanism of immunosuppressive action of Mizoribine. |
| Volume | 25(12) |
| Published | 2024-6-12 |
| DOI | 10.3390/ijms25126452 |
| PII | ijms25126452 |
| PMID | 38928158 |
| PMC | PMC11203801 |
| MeSH | Animals Chaperonin 60* / metabolism Humans Immunosuppressive Agents / pharmacology Interleukin-6* / metabolism Mice Ribonucleosides* / pharmacology |
| IF | 4.556 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Peer-review(Publons) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | THP-1 |