Reference - Detail
| RRC ID | 82135 |
|---|---|
| Author | Chow T, Humble W, Lucarelli E, Onofrillo C, Choong PF, Di Bella C, Duchi S. |
| Title | Feasibility and barriers to rapid establishment of patient-derived primary osteosarcoma cell lines in clinical management. |
| Journal | iScience |
| Abstract |
Osteosarcoma is a highly aggressive primary bone tumor that has seen little improvement in survival rates in the past three decades. Preclinical studies are conducted on a small pool of commercial cell lines which may not fully reflect the genetic heterogeneity of this complex cancer, potentially hindering translatability of in vitro results. Developing a single-site laboratory protocol to rapidly establish patient-derived primary cancer cell lines (PCCL) within a clinically actionable time frame of a few weeks will have significant scientific and clinical ramifications. These PCCL can widen the pool of available cell lines for study while patient-specific data could derive therapeutic correlation. This endeavor is exceedingly challenging considering the proposed time constraints. By proposing key definitions and a clear theoretical framework, this evaluation of osteosarcoma cell line establishment methodology over the past three decades assesses feasibility by identifying barriers and suggesting solutions, thereby facilitating systematic experimentation and optimization. |
| Volume | 27(9) |
| Pages | 110251 |
| Published | 2024-9-20 |
| DOI | 10.1016/j.isci.2024.110251 |
| PII | S2589-0042(24)01476-7 |
| PMID | 39286504 |
| PMC | PMC11403063 |
| IF | 4.447 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | NOS-1(RCB1032) NOS-2(RCB1033) NOS-10(RCB2348) |