論文 - 詳細
| RRC ID | 82463 |
|---|---|
| 著者 | Mehjabin JJ, Phan CS, Okino T. |
| タイトル | Noducyclamides A1-A4, B1, and B2 from the Cyanobacterium Nodularia sp. NIES-3585. |
| ジャーナル | J Nat Prod |
| Abstract |
A chemical investigation of the hydrophilic fraction of a cultured Nodularia sp. (NIES-3585) afforded six new cyclic lipopeptides, noducyclamides A1-A4 (1-4) containing 10 amino acid residues and dodecapeptides noducyclamides B1 and B2 (5 and 6). The planar structures of these lipopeptides were elucidated based on the combination of HRMS and 1D and 2D NMR spectroscopic data analyses. These peptides are structurally analogous to laxaphycins and contain the nonproteinogenic amino acids 3-hydroxyvaline and 3-hydroxyleucine and a β-amino decanoic acid residue. The absolute configurations of the noducyclamides (1-6) were determined by acid hydrolysis, followed by advanced Marfey's analysis. Noducyclamide B1 (5) showed cytotoxic activities against MCF7 breast cancer cell lines with an IC50 value of 3.0 μg/mL (2.2 μM). |
| 巻・号 | 87(4) |
| ページ | 984-993 |
| 公開日 | 2024-4-26 |
| DOI | 10.1021/acs.jnatprod.3c01272 |
| PMID | 38587271 |
| MeSH | Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology Cyanobacteria* / chemistry Drug Screening Assays, Antitumor Female Humans Lipopeptides / chemistry Lipopeptides / pharmacology MCF-7 Cells Molecular Structure Nuclear Magnetic Resonance, Biomolecular Peptides, Cyclic* / chemistry Peptides, Cyclic* / pharmacology |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 藻類 | NIES-3585 |