論文 - 詳細
| RRC ID | 82465 |
|---|---|
| 著者 | Phan CS, Mehjabin JJ, Anas ARJ, Hayasaka M, Onoki R, Wang J, Umezawa T, Washio K, Morikawa M, Okino T. |
| タイトル | Nostosin G and Spiroidesin B from the Cyanobacterium Dolichospermum sp. NIES-1697. |
| ジャーナル | J Nat Prod |
| Abstract |
Chemical investigation of the cyanobacterium Dolichospermum sp. NIES-1697 afforded nostosin G (1), a linear tripeptide, spiroidesin B (2), and two known compounds, anabaenopeptins I (3) and J (4). Planar structures and absolute configurations for 1 and 2 were determined by 2D NMR, HRMS, Marfey's methodology, chiral-phase HPLC, and enzymatic degradation. Nostosin G (1) is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal, with potent trypsin inhibitory properties. The biosynthetic gene clusters for nostosin G (1) and spiroidesin B (2) were investigated based on the genome sequence of Dolichospermum sp. NIES-1697. |
| 巻・号 | 85(8) |
| ページ | 2000-2005 |
| 公開日 | 2022-8-26 |
| DOI | 10.1021/acs.jnatprod.2c00382 |
| PMID | 35948062 |
| MeSH | Cyanobacteria* / chemistry Lipopeptides Molecular Structure Nuclear Magnetic Resonance, Biomolecular Trypsin Tyrosine / analogs & derivatives |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 藻類 | NIES-1697 |