RRC ID 82468
Author Sugiura N, Agata K.
Title FGF-stimulated tendon cells embrace a chondrogenic fate with BMP7 in newt tissue culture.
Journal Dev Growth Differ
Abstract Newts can regenerate functional elbow joints after amputation at the joint level. Previous studies have suggested the potential contribution of cells from residual tendon tissues to joint cartilage regeneration. A serum-free tissue culture system for tendons was established to explore cell dynamics during joint regeneration. Culturing isolated tendons in this system, stimulated by regeneration-related factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor, led to robust cell migration and proliferation. Moreover, cells proliferating in an FGF-rich environment differentiated into Sox9-positive chondrocytes upon BMP7 introduction. These findings suggest that FGF-stimulated cells from tendons may aid in joint cartilage regeneration during functional elbow joint regeneration in newts.
Volume 66(3)
Pages 182-193
Published 2024-4-1
DOI 10.1111/dgd.12913
PMID 38342985
PMC PMC11457504
MeSH Animals Bone Morphogenetic Protein 7* / metabolism Bone Morphogenetic Protein 7* / pharmacology Cell Differentiation Chondrocytes* / metabolism Fibroblast Growth Factors* / metabolism Fibroblast Growth Factors* / pharmacology Salamandridae / metabolism Tendons / metabolism
Resource
Clawed frogs / Newts Pleurodeles waltl