論文 - 詳細
| RRC ID | 82468 |
|---|---|
| 著者 | Sugiura N, Agata K. |
| タイトル | FGF-stimulated tendon cells embrace a chondrogenic fate with BMP7 in newt tissue culture. |
| ジャーナル | Dev Growth Differ |
| Abstract |
Newts can regenerate functional elbow joints after amputation at the joint level. Previous studies have suggested the potential contribution of cells from residual tendon tissues to joint cartilage regeneration. A serum-free tissue culture system for tendons was established to explore cell dynamics during joint regeneration. Culturing isolated tendons in this system, stimulated by regeneration-related factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor, led to robust cell migration and proliferation. Moreover, cells proliferating in an FGF-rich environment differentiated into Sox9-positive chondrocytes upon BMP7 introduction. These findings suggest that FGF-stimulated cells from tendons may aid in joint cartilage regeneration during functional elbow joint regeneration in newts. |
| 巻・号 | 66(3) |
| ページ | 182-193 |
| 公開日 | 2024-4-1 |
| DOI | 10.1111/dgd.12913 |
| PMID | 38342985 |
| PMC | PMC11457504 |
| MeSH | Animals Bone Morphogenetic Protein 7* / metabolism Bone Morphogenetic Protein 7* / pharmacology Cell Differentiation Chondrocytes* / metabolism Fibroblast Growth Factors* / metabolism Fibroblast Growth Factors* / pharmacology Salamandridae / metabolism Tendons / metabolism |
| IF | 1.723 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ツメガエル・イモリ | Pleurodeles waltl |